Collection of Actinomycetes

Research & Outreach

Currently finished projects:

1. Unique biosynthetic enzymes as the key to novel bioactive compounds

Ministry of Healthcare of the Czech Republic (2017-2020), No. 17-30091A

Principal investigator: Mgr. Kateřina Petříčková, PhD., University of South Bohemia in České Budějovice, Faculty of Science, České Budějovice


RNDr. Alica Chroňáková, PhD., Biology Centre CAS, Institute of Soil Biology, České Budějovice

Ing. Miroslav Petříček, PhD. The First Faculty of Medicine, Charles University in Prague


2. Towards novel bioactive compounds: characterization of specialized metabolites encoded on unique biosynthetic gene clusters

Czech Academy of Sciences - DAAD project (2018-2019), No. DAAD-18-02

Principal investigators:

RNDr. Alica Chroňáková, PhD., Biology Centre CAS, Institute of Soil Biology, České Budějovice

prof. Leonard Kaysser, Ph.D. Eberhard-Karls-Universität Tübingen, Inst. Pharmaceutical Biology, Germany



  • Lara A. C., Corretto E., Kotrbová L., Lorenc F., Petříčková K., Grabic R., Chroňáková A. (2021). The Genome Analysis of the Human Lung-Associated Streptomyces sp. TR1341 Revealed the Presence of Beneficial Genes for Opportunistic Colonization of Human Tissues. Microorganisms, 9(8), 1547.
  • Gorniaková, D., Petříček, M., Kahoun, D., Grabic, R., Zelenka, T., Chroňáková, A., & Petříčková, K. (2021). Activation of a Cryptic Manumycin-Type Biosynthetic Gene Cluster of Saccharothrix espanaensis DSM44229 by Series of Genetic Manipulations. Microorganisms, 9(3), 559.
  • Hrdý, J., Súkeníková, L., Petrásková, P., Novotná, O., Kahoun, D., Petříček, M., Chroňáková, A. & Petříčková, K. (2020). Inhibition of Pro-Inflammatory Cytokines by Metabolites of Streptomycetes—A Potential Alternative to Current Anti-Inflammatory Drugs?. Microorganisms, 8(5), 621.
  • Herbrík, A., Corretto, E., Chroňáková, A., Langhansová, H., Petrásková, P., Hrdý, J., Čihák, M., Krištůfek, V., Bobek, J., Petříček, M. & Petříčková, K. (2020). A human lung-associated Streptomyces sp. TR1341 produces various secondary metabolites responsible for virulence, cytotoxicity and modulation of immune response. Frontiers in microbiology, 10, 3028.
  • Petříček, M., Petříčková, K., Pospíšil, S., Kuzma, M., Chroňáková, A., Krištůfek, V., & Stříž, I. (2016). U.S. Patent No. 9,447,062. Washington, DC: U.S. Patent and Trademark Office. U.S. Patent No. 9,447,062. 20 Sep. 2016.
  • Řeháková, K., Chroňáková, A., Krištůfek, V., Kuchtová, B., Čapková, K., Scharfen, J., Čapek, P. & Doležal, J. (2015). Bacterial community of cushion plant Thylacospermum ceaspitosum on elevational gradient in the Himalayan cold desert. Frontiers in microbiology, 6
  • Petříčková, K., Chroňáková, A., Zelenka, T., Chrudimský, T., Pospíšil, S., Petříček, M., & Krištůfek, V. (2015). Evolution of cyclizing 5-aminolevulinate synthases in the biosynthesis of actinomycete secondary metabolites: outcomes for genetic screening techniques. Frontiers in microbiology, 6
  • Petříčková, K., Pospíšil, S., Kuzma, M., Tylová, T., Jágr, M., Tomek, P., Chroňáková, A., Brabcová, E., Anděra, L., Krištůfek, V. & Petríček, M. (2014). Biosynthesis of Colabomycin E, a New Manumycin-Family Metabolite, Involves an Unusual Chain-Length Factor. ChemBioChem 15, 1334-1345.
  • Chroňáková, A., Krištůfek, V., Tichý, M. & Elhottová, D. (2010). Biodiversity of streptomycetes isolated from a succession sequence at a post-mining site and their evidence in Miocene lacustrine sediment. Microbiological Research 165, 594-608.
  • Scharfen, J., Bunček, M., Ježek, P., Urbášková, P., Fridrichová, M., Krištůfek, V., & Chroňáková, A. (2010). Filamentous" contaminants" in the mycobacteriology laboratory; their culture, identification and clinical significance. Klinicka Mikrobiologie a Infekcni Lekarstvi, 16(2), 48-57.

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