Collection of Actinomycetes

Research & Outreach

Currently finished projects:

1. Unique biosynthetic enzymes as the key to novel bioactive compounds

Ministry of Healthcare of the Czech Republic (2017-2020), No. 17-30091A

Principal investigator: Mgr. Kateřina Petříčková, PhD., University of South Bohemia in České Budějovice, Faculty of Science, České Budějovice

Co-investigators: 

RNDr. Alica Chroňáková, PhD., Biology Centre CAS, Institute of Soil Biology, České Budějovice

Ing. Miroslav Petříček, PhD. The First Faculty of Medicine, Charles University in Prague

 

2. Towards novel bioactive compounds: characterization of specialized metabolites encoded on unique biosynthetic gene clusters

Czech Academy of Sciences - DAAD project (2018-2019), No. DAAD-18-02

Principal investigators:

RNDr. Alica Chroňáková, PhD., Biology Centre CAS, Institute of Soil Biology, České Budějovice

prof. Leonard Kaysser, Ph.D. Eberhard-Karls-Universität Tübingen, Inst. Pharmaceutical Biology, Germany

 

Publications

  • Lara A. C., Corretto E., Kotrbová L., Lorenc F., Petříčková K., Grabic R., Chroňáková A. (2021). The Genome Analysis of the Human Lung-Associated Streptomyces sp. TR1341 Revealed the Presence of Beneficial Genes for Opportunistic Colonization of Human Tissues. Microorganisms, 9(8), 1547.https://doi.org/10.3390/microorganisms9081547
  • Gorniaková, D., Petříček, M., Kahoun, D., Grabic, R., Zelenka, T., Chroňáková, A., & Petříčková, K. (2021). Activation of a Cryptic Manumycin-Type Biosynthetic Gene Cluster of Saccharothrix espanaensis DSM44229 by Series of Genetic Manipulations. Microorganisms, 9(3), 559.  https://doi.org/10.3390/microorganisms9030559
  • Hrdý, J., Súkeníková, L., Petrásková, P., Novotná, O., Kahoun, D., Petříček, M., Chroňáková, A. & Petříčková, K. (2020). Inhibition of Pro-Inflammatory Cytokines by Metabolites of Streptomycetes—A Potential Alternative to Current Anti-Inflammatory Drugs?. Microorganisms, 8(5), 621.  https://doi.org/10.3390/microorganisms8050621
  • Herbrík, A., Corretto, E., Chroňáková, A., Langhansová, H., Petrásková, P., Hrdý, J., Čihák, M., Krištůfek, V., Bobek, J., Petříček, M. & Petříčková, K. (2020). A human lung-associated Streptomyces sp. TR1341 produces various secondary metabolites responsible for virulence, cytotoxicity and modulation of immune response. Frontiers in microbiology, 10, 3028. https://doi.org/10.3389/fmicb.2019.03028
  • Petříček, M., Petříčková, K., Pospíšil, S., Kuzma, M., Chroňáková, A., Krištůfek, V., & Stříž, I. (2016). U.S. Patent No. 9,447,062. Washington, DC: U.S. Patent and Trademark Office. U.S. Patent No. 9,447,062. 20 Sep. 2016.
  • Řeháková, K., Chroňáková, A., Krištůfek, V., Kuchtová, B., Čapková, K., Scharfen, J., Čapek, P. & Doležal, J. (2015). Bacterial community of cushion plant Thylacospermum ceaspitosum on elevational gradient in the Himalayan cold desert. Frontiers in microbiology, 6 https://doi.org/10.3389/fmicb.2015.0030
  • Petříčková, K., Chroňáková, A., Zelenka, T., Chrudimský, T., Pospíšil, S., Petříček, M., & Krištůfek, V. (2015). Evolution of cyclizing 5-aminolevulinate synthases in the biosynthesis of actinomycete secondary metabolites: outcomes for genetic screening techniques. Frontiers in microbiology, 6https://doi.org/10.3389/fmicb.2015.00814
  • Petříčková, K., Pospíšil, S., Kuzma, M., Tylová, T., Jágr, M., Tomek, P., Chroňáková, A., Brabcová, E., Anděra, L., Krištůfek, V. & Petríček, M. (2014). Biosynthesis of Colabomycin E, a New Manumycin-Family Metabolite, Involves an Unusual Chain-Length Factor. ChemBioChem 15, 1334-1345.    https://doi.org/10.1002/cbic.201400068
  • Chroňáková, A., Krištůfek, V., Tichý, M. & Elhottová, D. (2010). Biodiversity of streptomycetes isolated from a succession sequence at a post-mining site and their evidence in Miocene lacustrine sediment. Microbiological Research 165, 594-608.  https://doi.org/10.1016/j.micres.2009.10.002
  • Scharfen, J., Bunček, M., Ježek, P., Urbášková, P., Fridrichová, M., Krištůfek, V., & Chroňáková, A. (2010). Filamentous" contaminants" in the mycobacteriology laboratory; their culture, identification and clinical significance. Klinicka Mikrobiologie a Infekcni Lekarstvi, 16(2), 48-57. https://europepmc.org/article/med/20503156

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